Ryan Reynolds in full Deadpool mode has returned for the sequel’s first trailer. The 20th Century Fox and Marvel‘s X-men-esque pic became the highest-earning R-rated film of all time with $783.1 million in global earnings. The new film introduces Josh Brolin’s Cable to new characters, including Zazie Beetz as Domino and Terry Crews. Plus, Brianna Hildebrand’s Negasonic Teenage Warhead and Stefan Kapicic‘s Colossus are back for more. Deadpool 2 lands May 18th.